Clinical and experimental phenotype of azole-resistant Aspergillus fumigatus with a HapE splice site mutation: a case report

Clinical and experimental phenotype of azole-resistant Aspergillus fumigatus with a HapE splice site mutation: a case report

Abstract Background The recent increase in cases of azole-resistant Aspergillus fumigatus (ARAf) infections is a major clinical concern owing to its treatment limitations. Patient-derived ARAf occurs after prolonged azole treatment in patients with aspergillosis and involves various cyp51A point mut...

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Bibliographic Details
Main Authors: Yuya Ito, Takahiro Takazono, Satoru Koga, Yuichiro Nakano, Nobuyuki Ashizawa, Tatsuro Hirayama, Masato Tashiro, Tomomi Saijo, Kazuko Yamamoto, Yoshifumi Imamura, Taiga Miyazaki, Katsunori Yanagihara, Koichi Izumikawa, Hiroshi Mukae
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Infectious Diseases
Subjects:
Chronic pulmonary aspergillosis
Azole-resistant Aspergillus fumigatus
Virulence
HapE
Online Access:https://doi.org/10.1186/s12879-021-06279-1

Internet

https://doi.org/10.1186/s12879-021-06279-1

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