Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins

Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins

Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets. Here, we use DEL screening against bromodomain and extra-term...

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Bibliographic Details
Main Authors: Seoyeon Jeong, Hwa-Ryeon Kim, June-Ha Shin, Min-Hee Son, In-Hyun Lee, Jae-Seok Roe
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Bioinformatics
DNA-encoded library
BET proteins
histone acetylation
MYC
epigenetic therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123001099

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http://www.sciencedirect.com/science/article/pii/S2162253123001099

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