Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins
Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets. Here, we use DEL screening against bromodomain and extra-term...
Main Authors: | Seoyeon Jeong, Hwa-Ryeon Kim, June-Ha Shin, Min-Hee Son, In-Hyun Lee, Jae-Seok Roe |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-06-01
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Series: | Molecular Therapy: Nucleic Acids |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253123001099 |
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