<i>N</i>-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy
The accumulation of saturated very long-chain fatty acids (VLCFA, ≥C22:0) due to peroxisomal impairment leads to oxidative stress and neurodegeneration in X-linked adrenoleukodystrophy (ALD). Among the neural supporting cells, myelin-producing oligodendrocytes are the most sensitive to the detriment...
| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado: |
MDPI AG
2021-12-01
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| Series: | Biomedicines |
| Subjects: | |
| Acceso en liña: | https://www.mdpi.com/2227-9059/9/12/1826 |