In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes

In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes

In the current study, chromatographic and in silico techniques were applied to investigate the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxoethyl)-2-methyl-1<i>H</i>-pyrrole-3-carboxylate (<b>11b</b>) in hepatocytic media. The i...

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Bibliographic Details
Main Authors: Alexandrina Mateeva, Magdalena Kondeva-Burdina, Emilio Mateev, Paraskev Nedialkov, Karolina Lyubomirova, Lily Peikova, Maya Georgieva, Alexander Zlatkov
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
biotransformation
chromatographic methods
in silico approaches
metabolism
pyrrole–hydrazone
synthesis
Online Access:https://www.mdpi.com/1420-3049/29/7/1474

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https://www.mdpi.com/1420-3049/29/7/1474

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