Distinct states of nucleolar stress induced by anticancer drugs

Distinct states of nucleolar stress induced by anticancer drugs

Ribosome biogenesis is a vital and highly energy-consuming cellular function occurring primarily in the nucleolus. Cancer cells have an elevated demand for ribosomes to sustain continuous proliferation. This study evaluated the impact of existing anticancer drugs on the nucleolus by screening a libr...

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Bibliographic Details
Main Authors: Tamara A Potapova, Jay R Unruh, Juliana Conkright-Fincham, Charles AS Banks, Laurence Florens, David Alan Schneider, Jennifer L Gerton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
nucleolus
anticancer drugs
RNA Pol I
CDK9
TCOF1/Treacle
Online Access:https://elifesciences.org/articles/88799

Internet

https://elifesciences.org/articles/88799

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