Localized Antileptin Therapy Prevents Aortic Root Dilatation and Preserves Left Ventricular Systolic Function in a Murine Model of Marfan Syndrome

Localized Antileptin Therapy Prevents Aortic Root Dilatation and Preserves Left Ventricular Systolic Function in a Murine Model of Marfan Syndrome

Background Marfan syndrome (MFS) is a genetically transmitted connective tissue disorder characterized by aortic root dilatation, dissection, and rupture. Molecularly, MFS pathological features have been shown to be driven by increased angiotensin II in the aortic wall. Using an angiotensin II–drive...

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Bibliographic Details
Main Authors: Sudeshna Fisch, Noa Bachner‐Hinenzon, Offir Ertracht, Liang Guo, Yhara Arad, Danny Ben‐Zvi, Ronglih Liao, Jacob Schneiderman
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aortic aneurysm
leptin antagonist
local therapy
Marfan syndrome
systolic dysfunction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.014761

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.014761

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