Alterations in Progesterone Receptor Isoform Balance in Normal and Neoplastic Breast Cells Modulates the Stem Cell Population

Alterations in Progesterone Receptor Isoform Balance in Normal and Neoplastic Breast Cells Modulates the Stem Cell Population

To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometr...

Full description

Bibliographic Details
Main Authors: María Sol Recouvreux, María Inés Diaz Bessone, Agustina Taruselli, Laura Todaro, María Amparo Lago Huvelle, Rocío G. Sampayo, Mina J. Bissell, Marina Simian
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
progesterone receptor isoforms
mammary gland
breast cancer
estrogen receptor
stem cells
Online Access:https://www.mdpi.com/2073-4409/9/9/2074

Internet

https://www.mdpi.com/2073-4409/9/9/2074

Similar Items