Cryptococcus neoformans rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia

Cryptococcus neoformans rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia

ABSTRACTCryptococcus neoformans causes lethal meningitis and accounts for approximately 10%–15% of AIDS-associated deaths worldwide. There are major gaps in our understanding of how this fungus invades the mammalian brain. To investigate the dynamics of C. neoformans tissue invasion, we mapped funga...

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Bibliographic Details
Main Authors: Vanessa I. Francis, Corin Liddle, Emma Camacho, Madhura Kulkarni, Samuel R. S. Junior, Jamie A. Harvey, Elizabeth R. Ballou, Darren D. Thomson, Gordon D. Brown, J. Marie Hardwick, Arturo Casadevall, Jonathan Witton, Carolina Coelho
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
microglia
Cryptococcus neoformans
blood-brain barrier
Online Access:https://journals.asm.org/doi/10.1128/mbio.03078-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03078-23

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