Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice

Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice

Microcystin-LR (MC-LR) is an extremely poisonous cyanotoxin that poses a threat to ecosystems and human health. MC-LR has been reported as an enterotoxin. The objective of this study was to determine the effect and the mechanism of subchronic MC-LR toxicity on preexisting diet-induced colorectal dam...

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Bibliographic Details
Main Authors: Yue Yang, Shuilin Zheng, Hanyu Chu, Can Du, Mengshi Chen, Mohammed Y. Emran, Jihua Chen, Fei Yang, Li Tian
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Toxins
Subjects:
microcystin-LR
colorectal injury
subchronic toxicity
high-fat diet
inflammation responses
Online Access:https://www.mdpi.com/2072-6651/15/4/262

Internet

https://www.mdpi.com/2072-6651/15/4/262

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