Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA).

Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA).

The genes PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Cα and Cβ, respectively. Cα is expressed in all eukaryotic tissues examined and studies of Cα knockout mice demonstrate a crucial role for Cα in normal physiology. We have sequenced exon 2 through 10 of...

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Autori principali: Kristoffer Søberg, Anja C V Larsen, Mandy Diskar, Paul H Backe, Magnar Bjørås, Tore Jahnsen, Jon K Laerdahl, Torbjørn Rognes, Friedrich W Herberg, Bjørn S Skålhegg
Natura: Articolo
Lingua:English
Pubblicazione: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3325940?pdf=render

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http://europepmc.org/articles/PMC3325940?pdf=render

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