VirB, a key transcriptional regulator of Shigella virulence, requires a CTP ligand for its regulatory activities

VirB, a key transcriptional regulator of Shigella virulence, requires a CTP ligand for its regulatory activities

ABSTRACT The VirB protein, encoded by the large virulence plasmid of Shigella spp., is a key transcriptional regulator of virulence genes. Without virB, Shigella cells are avirulent. On the virulence plasmid, VirB functions to offset transcriptional silencing mediated by the nucleoid structuring pro...

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Bibliographic Details
Main Authors: Taylor M. Gerson, Audrey M. Ott, Monika M. A. Karney, Jillian N. Socea, Daren R. Ginete, Lakshminarayan M. Iyer, L. Aravind, Ronald K. Gary, Helen J. Wing
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
bacterial gene regulation
large plasmids
transcriptional silencing/anti-silencing
ParB/Spo0J
GFP fusions
focus formation
Online Access:https://journals.asm.org/doi/10.1128/mbio.01519-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01519-23

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