Novel oxicam nonsteroidal compound XK01 attenuates inflammation by suppressing the NF-κB and MAPK pathway in RAW264.7 macrophages

Novel oxicam nonsteroidal compound XK01 attenuates inflammation by suppressing the NF-κB and MAPK pathway in RAW264.7 macrophages

Traditional non-steroidal anti-inflammatory drugs (NSAIDs) show serious adverse effects during clinical use, which limits their usage. Oxicams (e.g., piroxicam, meloxicam) are widely used as NSAIDs. However, selectivity to cyclooxygenase (COX) 2 may cause cardiovascular problems considering the long...

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Bibliographic Details
Main Authors: Jixiang Wang, Jiawang Tan, Qianmei Hu, Siyu Mao, Hongting Chen, Weiyi Luo, Xing Feng
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Inflammation
Oxicams
Cyclooxygenase
Macrophages
NF-κB signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024000355

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http://www.sciencedirect.com/science/article/pii/S2405844024000355

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