Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Abstract Accumulation of amyloid beta protein (Aβ) in brain vessels damages blood brain barrier (BBB) integrity in cerebral amyloid angiopathy (CAA). Macrophage lineage cells scavenge Aβ and produce disease-modifying mediators. Herein, we report that Aβ40-induced macrophage-derived migrasomes are st...

Full description

Bibliographic Details
Main Authors: Mengyan Hu, Tiemei Li, Xiaomeng Ma, Sanxin Liu, Chunyi Li, Zhenchao Huang, Yinyao Lin, Ruizhen Wu, Shisi Wang, Danli Lu, Tingting Lu, Xuejiao Men, Shishi Shen, Huipeng Huang, Yuxin Liu, Kangyu Song, Banghao Jian, Yuxuan Jiang, Wei Qiu, Quentin Liu, Zhengqi Lu, Wei Cai
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39693-x

Internet

https://doi.org/10.1038/s41467-023-39693-x

Similar Items