PIP5Kγ Mediates PI(4,5)P2/Merlin/LATS1 Signaling Activation and Interplays with Hsc70 in Hippo–YAP Pathway Regulation

PIP5Kγ Mediates PI(4,5)P2/Merlin/LATS1 Signaling Activation and Interplays with Hsc70 in Hippo–YAP Pathway Regulation

The type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family produces the critical lipid regulator phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in the plasma membrane (PM). Here, we investigated the potential role of PIP5Kγ, a PIP5K isoform, in the Hippo pathway. The ectopic expression o...

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Bibliographic Details
Main Authors: Duong Duy Thai Le, Truc Phan Hoang Le, Sang Yoon Lee
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
PIP5Kγ
Hippo–YAP pathway
PI(4,5)P2
Merlin
LATS1
Hsc70
Online Access:https://www.mdpi.com/1422-0067/24/19/14786

Internet

https://www.mdpi.com/1422-0067/24/19/14786

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