Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology

Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology

Abstract Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while the entorhinal cortex (EC) is one of the most vulnerable regions. Using a knock-in AD mouse model (App KI), we show that within the cerebellum,...

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Bibliographic Details
Main Authors: Jessica R. Gaunt, Norliyana Zainolabidin, Alaric K. K. Yip, Jia Min Tan, Aloysius Y. T. Low, Albert I. Chen, Toh Hean Ch’ng
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Microglia
Interferon
Deep cerebellar nuclei
CSF1R inhibitor
Entorhinal cortex
Online Access:https://doi.org/10.1186/s12974-023-02913-8

Internet

https://doi.org/10.1186/s12974-023-02913-8

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