Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN

Abstract The liver plays an important role in lipid and glucose metabolism. Here, we show the role of human antigen R (HuR), an RNA regulator protein, in hepatocyte steatosis and glucose metabolism. We investigated the level of HuR in the liver of mice fed a normal chow diet (NCD) and a high-fat die...

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Bibliographic Details
Main Authors: Mi Tian, Jingjing Wang, Shangming Liu, Xinyun Li, Jingyuan Li, Jianmin Yang, Cheng Zhang, Wencheng Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03514-0