Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins

Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins

Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening bronchoconstriction. To fill this therapeutic gap, we examined a potential role for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)...

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Bibliographic Details
Main Authors: Robin A. Lu, Amir A. Zeki, Sumati Ram-Mohan, Nhan Nguyen, Yan Bai, Kenneth Chmiel, Stevan Pecic, Xingbin Ai, Ramaswamy Krishnan, Chandra C. Ghosh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
statin
bronchodilation
asthma
stretch
inflammation
mevalonate
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00469/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00469/full

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