Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr...

Full description

Bibliographic Details
Main Authors: Yukio eYamamura, Ryoma eMorigaki, Jiro eKasahara, Hironori eYokoyama, Akie eTanabe, Shinya eOkita, Hidetaka eKoizumi, Shinji eNagahiro, Ryuji eKaji, Satoshi eGoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cyclin-Dependent Kinase 5
Dopamine
Phosphorylation
Striatum
Cell signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00012/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00012/full

Similar Items