Tetraoctylammonium, a Long Chain Quaternary Ammonium Blocker, Promotes a Noncollapsed, Resting-Like Inactivated State in KcsA

Tetraoctylammonium, a Long Chain Quaternary Ammonium Blocker, Promotes a Noncollapsed, Resting-Like Inactivated State in KcsA

Alkylammonium salts have been used extensively to study the structure and function of potassium channels. Here, we use the hydrophobic tetraoctylammonium (TOA<sup>+</sup>) to shed light on the structure of the inactivated state of KcsA, a tetrameric prokaryotic potassium channel that ser...

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Bibliographic Details
Main Authors: Ana Marcela Giudici, Clara Díaz-García, Maria Lourdes Renart, Ana Coutinho, Manuel Prieto, José M. González-Ros, José Antonio Poveda
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
potassium channels
tetraalkylammonium salts
protein thermal stability
homo-FRET
C-type inactivation
binding affinity
Online Access:https://www.mdpi.com/1422-0067/22/2/490

Internet

https://www.mdpi.com/1422-0067/22/2/490

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