Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway

Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway

Objective: Acetaminophen (APAP) is one of the world's popular and safe painkillers, and overdose can cause severe liver damage and even acute liver failure. The effect and mechanism of the xanthohumol on acetaminophen-induced hepatotoxicity remains unclear. Methods: The hepatoprotective effects...

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Bibliographic Details
Main Authors: Laiyu Zhu, Xiaoye Fan, Chunyuan Cao, Kailiang Li, Wenli Hou, Xinxin Ci
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acetaminophen
Hepatotoxicity
Oxidative stress
Xanthohumol
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223008880

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http://www.sciencedirect.com/science/article/pii/S0753332223008880

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