Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies

Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies

Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-MSC-EVs) have become an emerging strategy for treating various autoimmune and metabolic disorders, particularly diabetes. Delivery of UC-MSC-EVs is essential to ensure optimal efficacy of UC-MSC-EVs. To develop safe and superior...

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Bibliographic Details
Main Authors: Junfeng Li, Hirotake Komatsu, Erasmus K. Poku, Tove Olafsen, Kelly X. Huang, Lina A. Huang, Junie Chea, Nicole Bowles, Betty Chang, Jeffrey Rawson, Jiangling Peng, Anna M. Wu, John E. Shively, Fouad R. Kandeel
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceuticals
Subjects:
extracellular vesicles (EVs)
umbilical cord mesenchymal stem cell (UCMSC)
diabetes
I-124
positron emission tomography (PET)
intravenous (I.V.) administration
Online Access:https://www.mdpi.com/1424-8247/15/5/595

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https://www.mdpi.com/1424-8247/15/5/595

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