The Immunomodulatory Effects of Fluorescein-Mediated Sonodynamic Treatment Lead to Systemic and Intratumoral Depletion of Myeloid-Derived Suppressor Cells in a Preclinical Malignant Glioma Model

The Immunomodulatory Effects of Fluorescein-Mediated Sonodynamic Treatment Lead to Systemic and Intratumoral Depletion of Myeloid-Derived Suppressor Cells in a Preclinical Malignant Glioma Model

Fluorescein-mediated sonodynamic therapy (FL-SDT) is an extremely promising approach for glioma treatment, resulting from the combination of low-intensity focused ultrasound (FUS) with a sonosensitizer. In the present study, we evaluated the efficacy and immunomodulation of SDT with fluorescein as t...

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Bibliographic Details
Main Authors: Serena Pellegatta, Nicoletta Corradino, Manuela Zingarelli, Edoardo Porto, Matteo Gionso, Arianna Berlendis, Gianni Durando, Martina Maffezzini, Silvia Musio, Domenico Aquino, Francesco DiMeco, Francesco Prada
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
sonodynamic therapy
fluorescein
ultrasound
glioma
immune microenvironment
mouse model
Online Access:https://www.mdpi.com/2072-6694/16/4/792

Internet

https://www.mdpi.com/2072-6694/16/4/792

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