Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

Edmunds et al. examine how the adenosine receptor A2AR and the checkpoint molecule TIM3 suppress the killing of Renca tumors expressing hemagglutinin (HA) as a model neo-antigen by CL4 TCR transgenic T cells, which recognize an HA peptide presented by H-2Kd. The authors report that TIM3, which is up...

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Bibliographic Details
Main Authors: Grace L. Edmunds, Carissa C. W. Wong, Rachel Ambler, Emily J. Milodowski, Hanin Alamir, Stephen J. Cross, Gabriella Galea, Christoph Wülfing, David J. Morgan
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02972-8

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https://doi.org/10.1038/s42003-021-02972-8

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