Downregulation of Fat Mass and Obesity-Related Protein in the Anterior Cingulate Cortex Participates in Anxiety- and Depression-Like Behaviors Induced by Neuropathic Pain

Downregulation of Fat Mass and Obesity-Related Protein in the Anterior Cingulate Cortex Participates in Anxiety- and Depression-Like Behaviors Induced by Neuropathic Pain

N6-methyladenosine (m6A) is the most abundant methylation modification on mRNA in mammals. Fat mass and obesity-related protein (FTO) is the main RNA m6A demethylase. FTO is involved in the occurrence and maintenance of neuropathic pain (NP). NP often induces mental disorders. We found that NP downr...

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Bibliographic Details
Main Authors: Xiao-Ling Wang, Xin Wei, Jing-Jing Yuan, Yuan-Yuan Mao, Zhong-Yu Wang, Na Xing, Han-Wen Gu, Cai-Hong Lin, Wen-Ting Wang, Wei Zhang, Fei Xing
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuropathic pain
anterior cingulate cortex
anxiety-like behavior
depression-like behavior
fat mass and obesity-related protein
matrix metalloproteinase-9
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.884296/full

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https://www.frontiersin.org/articles/10.3389/fncel.2022.884296/full

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