Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2

Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2

Abstract The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases. However, the inherent inflammatory nature of OMV limits their use as human vaccines. This study employed an engineered vesicle technology to d...

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Bibliographic Details
Main Authors: Kyong-Su Park, Kristina Svennerholm, Rossella Crescitelli, Cecilia Lässer, Inta Gribonika, Mickael Andersson, Jonas Boström, Hanna Alalam, Ali M Harandi, Anne Farewell, Jan Lötvall
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Nanobiotechnology
Subjects:
Synthetic bacterial vesicles
Outer membrane vesicles
Vaccine
Pulmonary inflammation
Sepsis
COVID-19
Online Access:https://doi.org/10.1186/s12951-023-01928-w

Internet

https://doi.org/10.1186/s12951-023-01928-w

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