Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release
Terpenes are naturally occurring compounds produced by plants that are of great commercial interest in the food, agricultural, cosmetic, and pharmaceutical industries due to their broad spectra of antibacterial, antifungal, anthelmintic, membrane permeation enhancement, and antioxidant biological ac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/6/1207 |
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| author | Ernesto R. Soto Florentina Rus Hanchen Li Carli Garceau Jeffrey Chicca Mostafa Elfawal David Gazzola Martin K. Nielsen Joseph F. Urban Raffi V. Aroian Gary R. Ostroff |
| author_facet | Ernesto R. Soto Florentina Rus Hanchen Li Carli Garceau Jeffrey Chicca Mostafa Elfawal David Gazzola Martin K. Nielsen Joseph F. Urban Raffi V. Aroian Gary R. Ostroff |
| author_sort | Ernesto R. Soto |
| collection | DOAJ |
| description | Terpenes are naturally occurring compounds produced by plants that are of great commercial interest in the food, agricultural, cosmetic, and pharmaceutical industries due to their broad spectra of antibacterial, antifungal, anthelmintic, membrane permeation enhancement, and antioxidant biological activities. Applications of terpenes are often limited by their volatility and the need for surfactants or alcohols to produce stable, soluble (non-precipitated) products. Yeast particles (YPs) are hollow, porous microspheres that have been used for the encapsulation of terpenes (YP terpenes) by passive diffusion of terpenes through the porous YP cell walls. We here report the development of a second generation YP encapsulated terpene technology that incorporates the stimuli-responsive control of terpene release using biodegradable pro-terpene compounds (YP pro-terpenes). YP terpenes and YP pro-terpenes were both produced, in which high levels of carvacrol, eugenol, thymol and geraniol were encapsulated. The YP pro-terpenes show higher encapsulation stability than YP terpenes due to pro-terpenes being non-volatile solids at room temperature and stable in suspensions at neutral pH. YP pro-terpenes and YP terpenes were evaluated for biological activity in antibacterial, antifungal and anthelmintic assays. The YP pro-terpenes retained the full biological activity of the parent terpene compound. |
| first_indexed | 2024-03-10T11:01:03Z |
| format | Article |
| id | doaj.art-fc6ecae67f60415d9f921e0017ebfd98 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T11:01:03Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-fc6ecae67f60415d9f921e0017ebfd982023-11-21T21:34:11ZengMDPI AGFoods2304-81582021-05-01106120710.3390/foods10061207Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene ReleaseErnesto R. Soto0Florentina Rus1Hanchen Li2Carli Garceau3Jeffrey Chicca4Mostafa Elfawal5David Gazzola6Martin K. Nielsen7Joseph F. Urban8Raffi V. Aroian9Gary R. Ostroff10Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAM.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USABeltsville Human Nutrition Research Center, Diet, Genomics and Immunology Laboratory, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USATerpenes are naturally occurring compounds produced by plants that are of great commercial interest in the food, agricultural, cosmetic, and pharmaceutical industries due to their broad spectra of antibacterial, antifungal, anthelmintic, membrane permeation enhancement, and antioxidant biological activities. Applications of terpenes are often limited by their volatility and the need for surfactants or alcohols to produce stable, soluble (non-precipitated) products. Yeast particles (YPs) are hollow, porous microspheres that have been used for the encapsulation of terpenes (YP terpenes) by passive diffusion of terpenes through the porous YP cell walls. We here report the development of a second generation YP encapsulated terpene technology that incorporates the stimuli-responsive control of terpene release using biodegradable pro-terpene compounds (YP pro-terpenes). YP terpenes and YP pro-terpenes were both produced, in which high levels of carvacrol, eugenol, thymol and geraniol were encapsulated. The YP pro-terpenes show higher encapsulation stability than YP terpenes due to pro-terpenes being non-volatile solids at room temperature and stable in suspensions at neutral pH. YP pro-terpenes and YP terpenes were evaluated for biological activity in antibacterial, antifungal and anthelmintic assays. The YP pro-terpenes retained the full biological activity of the parent terpene compound.https://www.mdpi.com/2304-8158/10/6/1207terpenesyeast particlesantimicrobialanthelminticprodrug |
| spellingShingle | Ernesto R. Soto Florentina Rus Hanchen Li Carli Garceau Jeffrey Chicca Mostafa Elfawal David Gazzola Martin K. Nielsen Joseph F. Urban Raffi V. Aroian Gary R. Ostroff Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release Foods terpenes yeast particles antimicrobial anthelmintic prodrug |
| title | Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release |
| title_full | Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release |
| title_fullStr | Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release |
| title_full_unstemmed | Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release |
| title_short | Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release |
| title_sort | yeast particle encapsulation of scaffolded terpene compounds for controlled terpene release |
| topic | terpenes yeast particles antimicrobial anthelmintic prodrug |
| url | https://www.mdpi.com/2304-8158/10/6/1207 |
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