Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development.

Nearly 100% protection against malaria infection can be achieved in humans by immunization with P. falciparum radiation-attenuated sporozoites (RAS). Although it is thought that protection is mediated by T cell and antibody responses, only a few of the many pre-erythrocytic (sporozoite and liver sta...

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Main Authors: Joao C Aguiar, Jessica Bolton, Joyce Wanga, John B Sacci, Hideyuki Iriko, Julie K Mazeika, Eun-Taek Han, Keith Limbach, Noelle B Patterson, Martha Sedegah, Ann-Marie Cruz, Takafumi Tsuboi, Stephen L Hoffman, Daniel Carucci, Michael R Hollingdale, Eileen D Villasante, Thomas L Richie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4546230?pdf=render