Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

Mapping the genetic basis of complex traits is critical to uncovering the biological mechanisms that underlie disease and other phenotypes. Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can now explain much of the observed heritability...

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Bibliographic Details
Main Authors: Alex N Nguyen Ba, Katherine R Lawrence, Artur Rego-Costa, Shreyas Gopalakrishnan, Daniel Temko, Franziska Michor, Michael M Desai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
quantitative trait loci
pleiotropy
epistasis
polygenic traits
Online Access:https://elifesciences.org/articles/73983

Internet

https://elifesciences.org/articles/73983

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