Preparation and physicochemical characterization of sildenafil cocrystals

Preparation and physicochemical characterization of sildenafil cocrystals

Sildenafil is a specific inhibitor of the phosphodiesterase type 5 (PDE-5) enzyme that protects cyclic guanosine monophosphate from breakdown by PDE-5. It is a biopharmaceutical categorization system Class II medication with low bioavailability because it is almost insoluble in water. The objectives...

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Bibliographic Details
Main Authors: Somchai Sawatdee, Apichart Atipairin, Supitchaya Rakkummerd, Onsinee Suriyaphol, David J Harding, Poowadon Muenraya, Phimphaka Harding
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Journal of Advanced Pharmaceutical Technology & Research
Subjects:
aspirin
benzoic acid
cocrystal
fumaric acid
physicochemical properties
sildenafil
solubility
Online Access:http://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=4;spage=408;epage=419;aulast=Sawatdee

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http://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=4;spage=408;epage=419;aulast=Sawatdee

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