Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel

Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel

Abstract Rationale Cancer of unknown primary (CUP) is a group of rare malignancies with poor prognosis and unidentifiable tissue-of-origin. Distinct DNA methylation patterns in different tissues and cancer types enable the identification of the tissue of origin in CUP patients, which could help risk...

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Bibliographic Details
Main Authors: Miaomiao Sun, Bo Xu, Chao Chen, Youjie Zhu, Xiaomo Li, Kuisheng Chen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Clinical Epigenetics
Subjects:
Cancer of unknown primary
Methylation classifier
Tissue of origin
Machine learning
Random forest
Elastic net
Online Access:https://doi.org/10.1186/s13148-024-01638-6

Internet

https://doi.org/10.1186/s13148-024-01638-6

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