Propensity of selecting mutant parasites for the antimalarial drug cabamiquine

Propensity of selecting mutant parasites for the antimalarial drug cabamiquine

Abstract We report an analysis of the propensity of the antimalarial agent cabamiquine, a Plasmodium-specific eukaryotic elongation factor 2 inhibitor, to select for resistant Plasmodium falciparum parasites. Through in vitro studies of laboratory strains and clinical isolates, a humanized mouse mod...

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Bibliographic Details
Main Authors: Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimdé, Marcus C. S. Lee, Laurent Dembélé, David A. Fidock, David S. Khoury, Thomas Spangenberg
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40974-8

Internet

https://doi.org/10.1038/s41467-023-40974-8

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