Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differentiation signaling to reprogram fibroblasts

Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differentiation signaling to reprogram fibroblasts

Silica nanoparticle (SiNP) exposure induces severe pulmonary inflammation and fibrosis, but the pathogenesis remains unclear, and effective therapies are currently lacking. To explore the mechanism underlying SiNPs-induced pulmonary fibrosis, we constructed in vivo silica exposure animal models and...

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Bibliographic Details
Main Authors: Jiaqi Tian, Dandan Song, Yanjie Peng, Jing Zhang, Lan Ma, Zhen Chen, Liyang Liang, Zitong Zhang, Xiang Yun, Lin Zhang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Silica nanoparticle
Pulmonary fibrosis
Macrophage
Fibroblast
Pyroptosis
Transdifferentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324001817

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http://www.sciencedirect.com/science/article/pii/S0147651324001817

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