Therapeutic Potential of Regorafenib—A Multikinase Inhibitor in Pulmonary Hypertension

Therapeutic Potential of Regorafenib—A Multikinase Inhibitor in Pulmonary Hypertension

Pulmonary hypertension (PH) is characterized by a progressive elevation of mean arterial pressure followed by right ventricular failure and death. Previous studies have indicated that numerous inhibitors of receptor tyrosine kinase signaling could be either beneficial or detrimental for the treatmen...

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Bibliographic Details
Main Authors: Swathi Veeroju, Baktybek Kojonazarov, Astrid Weiss, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Tatyana Novoyatleva, Ralph Theo Schermuly
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
regorafenib (BAY 73-4506)
monocrotaline (MCT)
chronic hypoxia (HOX)
human pulmonary arterial smooth muscle cells
kinome analysis
pulmonary vascular remodeling
Online Access:https://www.mdpi.com/1422-0067/22/3/1502

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https://www.mdpi.com/1422-0067/22/3/1502

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