Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome

ABSTRACT The eukaryotic protozoan parasite Trypanosoma brucei is transmitted by the tsetse fly to both humans and animals, where it causes a fatal disease called African trypanosomiasis. While the parasite lacks canonical DNA sequence-specific transcription factors, it does possess histones, histone...

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Bibliographic Details
Main Authors: Ethan C. Ashby, Jennifer L. Havens, Lindsey M. Rollosson, Johanna Hardin, Danae Schulz
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
bromodomain proteins
epigenetics
gene regulation
molecular parasitology
parasite
Trypanosoma brucei
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00147-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00147-23

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