From bench to bedside: in vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy

From bench to bedside: in vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy

Abstract Background Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical challenges of depositing nebulized drugs in the lungs of preterm infants....

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Main Authors: F. Bianco, F. Ricci, C. Catozzi, X. Murgia, M. Schlun, A. Bucholski, U. Hetzer, S. Bonelli, M. Lombardini, E. Pasini, M. Nutini, M. Pertile, S. Minocchieri, M. Simonato, B. Rosa, G. Pieraccini, G. Moneti, L. Lorenzini, S. Catinella, G. Villetti, M. Civelli, B. Pioselli, P. Cogo, V. Carnielli, C. Dani, F. Salomone
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Respiratory Research
Subjects:
Nebulized surfactant
Poractant alfa
eFlow-Neos
Respiratory distress syndrome
CPAP
Neonatal ventilation
Online Access:http://link.springer.com/article/10.1186/s12931-019-1096-9

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http://link.springer.com/article/10.1186/s12931-019-1096-9

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