Box–Behnken Design Based Development of UV-Reversed Phase High Performance Liquid Chromatographic Method for Determination of Ascorbic Acid in Tablet Formulations

Box–Behnken Design Based Development of UV-Reversed Phase High Performance Liquid Chromatographic Method for Determination of Ascorbic Acid in Tablet Formulations

A simple, sensitive, accurate and inexpensive UV-reversed-phase high-performance liquid chromatographic method was developed for the determination of ascorbic acid in tablet formulations. The method was based on the separation of ascorbic acid using a mobile phase of an acetonitrile-NaH<sub>2&...

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Bibliographic Details
Main Authors: Syed Najmul Hejaz Azmi, Umaima Al Hoqani, Juhaina Obaid Said Al Mamari, Buthaina Mohamed Salim Al Mamari, Balaqis Sultan Ali Rashid Al Jassasi, Aziza Saleh Saif Al Rubaiai, Nafisur Rahman, Mohd Nasir, Sk Manirul Haque, Shah Alam Khan, Qamar Uddin Ahmed, Zainul Amiruddin Zakaria
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Separations
Subjects:
ascorbic acid
Box–Behnken design
HPLC
ICH
validation
Online Access:https://www.mdpi.com/2297-8739/9/11/361

Internet

https://www.mdpi.com/2297-8739/9/11/361

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