Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial

Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial

Background: In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18 weeks, followed by analytical treatment interruption (ATI) between weeks 28 and 52. Cell-med...

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Bibliographic Details
Main Authors: Yunda Huang, Giuseppe Pantaleo, Gonzalo Tapia, Brittany Sanchez, Lily Zhang, Monica Trondsen, Arnt-Ove Hovden, Richard Pollard, Jürgen Rockstroh, Mats Ökvist, Maja A. Sommerfelt
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:EBioMedicine
Subjects:
Analytical treatment interruption (ATI)
HIV
Therapeutic vaccine
Viral load
Immune predictors
CD4
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303821

Internet

http://www.sciencedirect.com/science/article/pii/S2352396417303821

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