Disruption in iron homeostasis and impaired activity of iron-sulfur cluster containing proteins in the yeast model of Shwachman-Diamond syndrome

Disruption in iron homeostasis and impaired activity of iron-sulfur cluster containing proteins in the yeast model of Shwachman-Diamond syndrome

Abstract Background Shwachman-Diamond syndrome (SDS) is a congenital disease that affects the bone marrow, skeletal system, and pancreas. The majority of patients with SDS have mutations in the SBDS gene, involved in ribosome biogenesis as well as other processes. A Saccharomyces cerevisiae model of...

Full description

Bibliographic Details
Main Authors: Ayushi Jain, Phubed Nilatawong, Narinrat Mamak, Laran T. Jensen, Amornrat Naranuntarat Jensen
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell & Bioscience
Subjects:
Shwachman-diamond syndrome
Iron overload
Yeast
Iron sulfur cluster
POR1 overexpression
Online Access:http://link.springer.com/article/10.1186/s13578-020-00468-2

Internet

http://link.springer.com/article/10.1186/s13578-020-00468-2

Similar Items