Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach

Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach

Visceral leishmaniasis (VL), caused by Leishmania infantum, is an oft-fatal neglected tropical disease. In the absence of an effective vaccine, the control of leishmaniasis relies exclusively on chemotherapy. Due to the lack of established molecular/genetic markers denoting parasite resistance, clin...

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Bibliographic Details
Main Authors: Ana Victoria Ibarra-Meneses, Audrey Corbeil, Victoria Wagner, Francis Beaudry, Rubens L. do Monte-Neto, Christopher Fernandez-Prada
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leishmania
antileishmanial drugs
mode of action
thermal proteome profiling
drug resistance
antimony
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.954144/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.954144/full

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