Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury: Physiological Role of Angiotensin II-Induced Oxidative Stress in Renal Medulla

Abstract.: Renal medullary circulation has now been found to play a fundamental role in regulating long-term blood pressure control and fluid balance. Elevation of superoxide or reduction of nitric oxide (NO) in renal medulla decreases medullary blood flow and Na excretion, resulting in sustained hy...

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Bibliographic Details
Main Authors: Takefumi Mori, Allen W. Cowley, Jr., Sadayoshi Ito
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319345311