Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis

Molecular mechanisms underpinning nonalcoholic fatty liver disease (NAFLD) are not well understood. The earliest step of NAFLD is hepatic steatosis, which is one of the main characteristics of aging liver. Here, we present a molecular scenario of age-related liver steatosis. We show that C/EBPα-S193...

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Bibliographic Details
Main Authors: Jingling Jin, Polina Iakova, Meghan Breaux, Emily Sullivan, Nicole Jawanmardi, Dahu Chen, Yanjun Jiang, Estela M. Medrano, Nikolai A. Timchenko
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713000685