A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological processes such as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and the excitability of neurons. Notwithstanding intense interest in the mechanism behind TMEM16A-CaCC ca...

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Bibliographic Details
Main Authors: Jason Tien, Christian J Peters, Xiu Ming Wong, Tong Cheng, Yuh Nung Jan, Lily Yeh Jan, Huanghe Yang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-06-01
Series:eLife
Subjects:
TMEM16 channel
calcium activated chloride channel
calcium binding site
TMEM16A channel
ANO1 channel
calcium dependent activation
Online Access:https://elifesciences.org/articles/02772

Internet

https://elifesciences.org/articles/02772

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