Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

Summary: Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Even small changes in sequence can alter receptor activation, affecting therapeutic efficacy. We conducted a structure-function relationship study on the neuropeptide TLQP-21, a promising targe...

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Bibliographic Details
Main Authors: Bhavani S. Sahu, Pedro Rodriguez, Megin E. Nguyen, Ruijun Han, Cheryl Cero, Maria Razzoli, Paolo Piaggi, Lauren J. Laskowski, Mihaela Pavlicev, Louis Muglia, Sushil K. Mahata, Scott O’Grady, John D. McCorvy, Leslie J. Baier, Yuk Y. Sham, Alessandro Bartolomucci
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719310174

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http://www.sciencedirect.com/science/article/pii/S2211124719310174

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