Brain vitamin D3-auto/paracrine system in relation to structural, neurophysiological, and behavioral disturbances associated with glucocorticoid-induced neurotoxicity

Brain vitamin D3-auto/paracrine system in relation to structural, neurophysiological, and behavioral disturbances associated with glucocorticoid-induced neurotoxicity

IntroductionVitamin D3 (VD3) is a potent para/autocrine regulator and neurosteroid that can strongly influence nerve cell function and counteract the negative effects of glucocorticoid (GC) therapy. The aim of the study was to reveal the relationship between VD3 status and behavioral, structural-fun...

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Main Authors: Olha Lisakovska, Dmytro Labudzynskyi, Anna Khomenko, Dmytro Isaev, Alina Savotchenko, Ludmila Kasatkina, Serhii Savosko, Mykola Veliky, Ihor Shymanskyi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glucocorticoids
glucocorticoid-induced neurotoxicity
prednisolone
vitamin D3
vitamin D-auto/paracrine system
oxidative-nitrosative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1133400/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1133400/full

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