Activation of IGF-1/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity

Activation of IGF-1/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity

Amyotrophic lateral sclerosis (ALS) is a severe adult motor neuron disease that causes progressive neuromuscular atrophy, muscle wasting, weakness, and depressive-like symptoms. Our previous research suggests that mercury levels are directly associated with ALS progression. MeHg+-induced ALS is char...

Full description

Bibliographic Details
Main Authors: Ambika Shandilya, Sidharth Mehan, Sumit Kumar, Pranshul Sethi, Acharan S. Narula, Abdulrahman Alshammari, Metab Alharbi, Abdullah F. Alasmari
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
amyotrophic lateral sclerosis
GLP-1
IGF-1
methylmercury
motor neuron death
4-hydroxyisoleucine
Online Access:https://www.mdpi.com/1420-3049/27/12/3878

Internet

https://www.mdpi.com/1420-3049/27/12/3878

Similar Items