Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. To begin to unravel whether mitochondrial ROS regulate pruning, we made the l...

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Bibliographic Details
Main Authors: Eva Sidlauskaite, Jack W. Gibson, Ian L. Megson, Philip D. Whitfield, Artak Tovmasyan, Ines Batinic-Haberle, Michael P. Murphy, Peter R. Moult, James N. Cobley
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718301447

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http://www.sciencedirect.com/science/article/pii/S2213231718301447

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