Rescuing ESAT-6 Specific CD4 T Cells From Terminal Differentiation Is Critical for Long-Term Control of Murine Mtb Infection

Rescuing ESAT-6 Specific CD4 T Cells From Terminal Differentiation Is Critical for Long-Term Control of Murine Mtb Infection

In most cases, Mycobacterium tuberculosis (Mtb) causes life-long chronic infections, which poses unique challenges for the immune system. Most of the current tuberculosis (TB) subunit vaccines incorporate immunodominant antigens and at this point, it is poorly understood how the CD4 T cell subsets r...

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Bibliographic Details
Main Authors: Helena Strand Clemmensen, Niels Peter Hell Knudsen, Rolf Billeskov, Ida Rosenkrands, Gregers Jungersen, Claus Aagaard, Peter Andersen, Rasmus Mortensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
vaccines
T cell differentiation
mouse models
ESAT-6
Mycobacterium tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.585359/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.585359/full

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