Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain

Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain

O-GlcNAcylation is a modification that alters the function of numerous proteins. We hypothesized that augmented O-GlcNAcylation levels enhance myosin light chain kinase (MLCK) and reduce myosin light chain phosphatase (MLCP) activity, leading to increased vascular contractile responsiveness. The vas...

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Bibliographic Details
Main Authors: V.V. Lima, N.S. Lobato, F.P. Filgueira, R.C. Webb, R.C. Tostes, F.R. Giachini
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2014-10-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
O-GlcNAcylation
Myosin light chain
Vascular reactivity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001000826&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001000826&lng=en&tlng=en

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