Novel Coumarin-Containing Aminophosphonatesas Antitumor Agent: Synthesis, Cytotoxicity, DNA-Binding and Apoptosis Evaluation

Novel Coumarin-Containing Aminophosphonatesas Antitumor Agent: Synthesis, Cytotoxicity, DNA-Binding and Apoptosis Evaluation

A series of novel coumarin-containing α-aminophosphonates were synthesized and evaluated for their antitumor activities against Human colorectal (HCT-116), human nasopharyngeal carcinoma (human KB) and human lung adenocarcinoma (MGC-803) cell lines in vitro. Compared with 7-hydroxy-4-methylcoumarin...

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Bibliographic Details
Main Authors: Ya-Jun Li, Cai-Yi Wang, Man-Yi Ye, Gui-Yang Yao, Heng-Shan Wang
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
7-hydroxy-4-methylcoumarin
α-aminophosphonates
synthesis
cytotoxicity
cell cycle
DNA binding
Online Access:http://www.mdpi.com/1420-3049/20/8/14791

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http://www.mdpi.com/1420-3049/20/8/14791

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